Regulation of Erythropoiesis

Regulation of erythropoiesis.

Regulation of Erythropoiesis . I . Erythropoietin Assay

By WARD D. N0YE5, BILL M. DO st AND LoRErrA C. Wails T HE RATE of red cell production is regulated by a plasma factor( s ) termed erythropoietin. While injection of exogenous plasma rich in this substance (or substances ) has been shown to induce an increase in the total circulating red cell mass by stimulation of erythropoiesis,13 quantitation of erythropoietin has been hampered by lack of spe...

Regulation of erythropoiesis by hypoxia-inducible factors.

A classic physiologic response to systemic hypoxia is the increase in red blood cell production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type specific gene expression changes that result in increased erythropoietin (EPO) production in kidney and liver, in enhanced iron uptake and utilization and in adjustments of the bone marrow microenvironment that facilita...

Hypoxic regulation of erythropoiesis and iron metabolism.

The kidney is a highly sensitive oxygen sensor and plays a central role in mediating the hypoxic induction of red blood cell production. Efforts to understand the molecular basis of oxygen-regulated erythropoiesis have led to the identification of erythropoietin (EPO), which is essential for normal erythropoiesis and to the purification of hypoxia-inducible factor (HIF), the transcription facto...

Developmental regulation of erythropoietin and erythropoiesis.

It is well established that erythropoiesis occurs first in the yolk sac, then in the liver, subsequently moving to the bone marrow and, in rodents, the spleen during development. The origin of the erythropoietic precursors and some factors suggested to be important for the changing location of erythropoiesis are discussed in this review. Until recently, the major site of erythropoietin (Epo) pr...